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Nanae Island is a man-made island in the Pacific Ocean that holds everything necessary for the proper education and training of children. It was created by the Great Seven, a group of adventurers headed by Nanana Ryuugajou, as a place for the young to chase their dreams. After being disowned and exiled by his family, high school student Juugo Yama arrives on this island, happy to finally be free of his father. Upon moving into his new room, he discovers the ghost of Nanana Ryuugajou, bound to the island after her unsolved murder 10 years ago. Nanana tells Juugo that, just before her death, she hid items with unique and mysterious powers all across the island—items known as the Nanana Collection. Hoping to uncover clues that will help him find the culprit behind her death, Juugo, with the help of self-proclaimed "Master Detective" Tensai Ikkyuu and her cross-dressing maid Daruku Hoshino, sets out on his search. [Written by MAL Rewrite]

On a quiet and peaceful day, the skies split open and extradimensional beings, designated as the Unknown, launch a swift and brutal attack against humanity. To protect the future of the country, all of Japan's children are cryogenically frozen until the end of the war to keep them out of harm's way. Several years pass, and humanity has established a foothold in a corner of Japan, which now serves as the frontline of the war. No longer facing humanity's extinction, the children are awakened from their slumber. It is then discovered that, while in cryogenesis, the children had developed Worlds, supernatural powers unique to each person. The six most powerful children are given command of the reclaimed cities, using their powers to defend the strongholds against the continuing invasion. Childhood friends Ichiya Suzaku and Canaria Utara lead Tokyo, siblings Kasumi and Asuha Chigusa manage Chiba, and Maihime Tenkawa and Hotaru Rindou oversee Kanagawa. Over time, the almost routine attacks from the Unknown and the clashing personalities of the city heads and subheads cultivate petty rivalries, leading to constant arguments between the three cities. With the Unknown suddenly increasing the pressure of their attacks, the three cities' leaders must learn how to work together or risk losing the last line of defense against humanity's extinction. [Written by MAL Rewrite]

The anime's original story features Mutta and Hibito during one summer when they were children. During the summer when Mutta and Hibito made their promise to go to space, they met a young girl who also had a wish. (Source: ANN)

The stage is Ayanagi City, a city near the Japan Sea. It is a futuristic city that was built to carry out the recovery from the calamity caused by the "Apathy Syndrome" ten years previous. High school student Shin Kanzato with his little brother Jun, meet with their elder brother Ryou, who is the chief of the Ayanagi City Police, again after ten years. At that time, a series of strange incidents happen in Ayanagi City such as the crew of a submarine that suddenly disappears while in their submarine, or a spiritless symptom which disturbs the world after ten years, or the case of the inside out corpse where a student took on a cruel appearance. Ryou tracks down the organization behind the string of incidents, and having become involved in the incidents, Shin awakens the "Persona." (Source: Wikipedia)